Cryopreserved cells maintain an average of over 90% viability and recovery when thawed
Fresh or cryopreserved products in various cell quantities
Available for clinical or research use
All cell products are supplied with relevant documentation, including Certificate of Analysis (CoA) and thawing instruction
Donors from specific demographics and disease states available upon request
Rapid shipping available
At Cell Generation, we supply human PBMCs for clinical and research use across a variety of fields in immunology, cell therapy, and immunotherapy. Our products are suitable for all in-vitro immunoassays, including those for ADCC and, ELISPOT, and mixed lymphocyte reactions. They meet the requirements for ex-vivo uses, including retroviral infection for the production of genetically modified cells and characterizing cell populations.
Our PBMC Sources
Cell Generation relies on an extensive, ethnically diverse network of healthy donors for our human PBMCs and leukopaks. These donors are thoroughly screened to ensure they are not positive for a comprehensive suite of infectious diseases and determine eligibility by a medical doctor. All donors are IRB-approved consented donors. For each collection a detailed Certificate of Analysis (COA) is supplied to bring the most comprehensive data set for any research application.
Our team takes every precaution to ensure that our customers receive a viable and high-quality PBMCs in every order. All processes, from donor screening to cryopreservation, follow current Good Manufacturing Practice (GMP) guidelines in order to ensure donor safety, and product high standard reproducibility. All lots undergo routine sampling and testing to guarantee our stringent quality standards are met. These samples undergo a full suite of testing for infectious diseases, fungi, mycoplasma, and more. Additional methods for determining cell count to ensure accuracy are used. A Certificate of Analysis (CoA) accompanies every shipment, showing the results of our extensive quality testing.
Our Cryopreservation Techniques
To ensure preservation while maintaining high viability and recovery, Cell Generation utilizes the latest cryopreservation methodology and techniques. Our cryopreservation protocols deliver high quality products while preventing contamination. These techniques gradually reduce the temperature of the PBMCs below -135 °C to allow for perfect preservation with average recovery and viability in excess of 90%. All cryopreserved products are supplied with relevant documentation and thawing instructions.
Available In:
50, 100, 150, 250, 500 X 106 Cells per vial fresh or cryopreserved.
1 x 109 Cells available fresh
Custom orders available
Species: Human
Cell Type: Mononuclear
Sample Format: Fresh or cryopreserved
Viability and recovery when thawed: Upwards of 85%
At Cell Generation, we collect PBMCs using leukapheresis separation. The process begins with donor screening including eligibility for blood donation prior to the apheresis procedure. Once the donor passes all relevant tests, a medical doctor reviews their results and grants them eligibility to proceed with the apheresis procedure. Our unique apheresis technique results in highly purified mononuclear cells. All throughout this process, we’re carefully following our quality control standard operating procedures to ensure that conditions remain sterile, and that product quality is maintained.
Clinical and Research Applications
Cell Generation PBMCs have applications in both clinical and research settings.
They play a critical role as starting material for cell clinical applications and research inclusing:
- Chimeric antigen receptor (CAR) T, NK applications
- PBMCS Subpopulations; T, B, NK, Dendritic cells, Monocytes
- Drug development
- Cell therapy tissue engineering
- Assay validation
- T cell research
- Mixed lymphocyte reaction assays
- Cytotoxicity research
- General immunology applications
PBMC research donor program
For your unique research requirements, we can provide donor requests as needed. Reach out to our team today with the requirements for your experiment, and we can help source the PBMCs you need, including requests for:
- Specific HLA typing, Class I and Class II alleles
- Specific demographics, sex, and ethnicity
- Specific health categories like BMI and smoking status
- Specific disease state
Cell Generation maintains a strong commitment to ensuring the ethical collection and use of all donor samples. We source our cells from consenting volunteer donors using Institutional Review Board (IRB) approved consent practices. Donors sign a consent form before taking part in the donation program, and industry best practice confidentiality measures are in place to ensure the privacy of all donors.
- Professional Experience
Our professional experts carry out all quality control and preservation activities with the benefit of years of experience and training in the latest methodologies. This ensures you get the highest quality and most reliable products. - We Work With You
Our team is ready to support your research endeavors in any way we can. From assay design to data analysis, our scientists can ensure you’re getting the accurate results you need with our reliable and well-documented samples. - Making Things Simple
We ensure that you’re not wasting precious research time on securing samples. With an extensive inventory, fast delivery, and responsive service, we can let your team focus on their research instead of sample procurement. - A Personal Touch
We understand how difficult the research landscape can be. That’s why we strive to provide the most reliable service for all of our valued customers. Reach out to us with any of your special requests, and we’ll do everything we can to find a suitable solution.
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